Abstract 3579: Prevalence And Distribution Of Asymptomatic Cervicocephalic Atherosclerosis In A Caucasian Population: Risk Factors And Biomarkers
Objective: To study clinical and biological factors associated with the different cervicocephalic location of atherosclerosis in Caucasian stroke-free individuals.
Methods: Carotid and intracranial atherosclerosis were assessed in the same lab by ECO-Doppler in a random sample population of 933 Caucasian subjects older than 50, with a moderate-high vascular risk and without history of stroke (64% males, mean age 66 years). Hypertension, dyslipemia, diabetes and smoking habit were defined based on clinical history and/or current medications. The following inflammatory and endothelial dysfunction biomarkers were determined at baseline and considered as continuous variables for the analyses: C-reactive protein (CRP), plasminogen activator inhibitor (PAI-1), resistin and asymmetric dimethylarginine (ADMA).
Results: Subjects were classified according to the cervicocephalic location of atherosclerotic lesions: 449 (48.1%) had no lesions (reference group), 404 (43.3%) had isolated carotid extracranial lesions (EC), 57 (6.1%) had isolated intracranial lesions (IC) and 23 (2.5%) had combined extra-intracranial lesions (C). After multinomial regression analyses, factors independently associated with each location of atherosclerosis compared to the reference group were: with EC, age (OR 1.06[1.04-1.09]p<0.001), male sex (OR 1.8[1.3-2.5]p=0.001), hypertension (OR 1.5[1.1-2]p=0.001), smoking (OR 1.7[1.2-2.4]p=0.004) and ADMA levels (1.7[1.05-2.9]p=0.03); with IC, age (OR 1.07[1.03-1.12]p<0.001), diabetes (OR 3.5[1.7-7.3]p=0.001) and ADMA levels (OR 3.2[1.3-8.1]p=0.01); with C, age (OR 1.2[1.05-1.2]p<0.001), male sex (OR 4.8[1.4-15.9]p<0.001), diabetes (OR 6.4[2.1-19.4]p=0.001), hypertension (OR 7.1[1.5-32.9]p=0.01) and resistin levels (OR 1.1[1.008-1.26]p=0.03).
Conclusions: Our findings show distinct clinical and biological signatures of the cervico-cephalic location of subclinical atherosclerosis.
- © 2012 by American Heart Association, Inc.