Advances in Stroke
Translational Medicine 2012
Translational stroke research continues to move ahead, despite several disappointing clinical trial failures in 2012. There are several factors believed to be contributing to the difficulties in translating experimental studies to human stroke, for example, experimental stroke models might vary too significantly from human stroke, there might be biases in some experimental findings, and the pathophysiology of acute brain injury caused by stroke might be different in humans and animals. The current critical assessment of preclinical studies is driving improvement in the quality of experimental studies and expanding the number of hurdles that a molecule must overcome before proceeding to clinical research. In this short overview, we describe selected translational stroke research that has taken place in 2012.
Currently, a candidate drug for successful translation is the postsynaptic density-95 protein (PSD-95) inhibitor, Tat-NR2B9c, which uncouples postsynaptic density protein PSD-95 from neurotoxic signaling pathways.1 PSD-95 binds N-methyl-D-aspartate GluN2 subunits and the neuronal NO synthase.2 Disrupting this complex with PSD-95 inhibitor administered after stroke onset in rodents and nonhuman …