Rating Method for Dilated Virchow–Robin Spaces on Magnetic Resonance Imaging
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Background and Purpose—Dilated Virchow–Robin spaces are an emerging neuroimaging biomarker, but their assessment on MRI needs standardization.
Methods—We developed a rating method for dilated Virchow–Robin spaces in 4 brain regions (centrum semiovale, basal ganglia, hippocampus, and mesencephalon) and tested its reliability in a total of 125 MRI scans from 2 population-based studies. Six investigators with varying levels of experience performed the ratings. Intraclass correlation coefficients were calculated to determine intra- and interrater reliability.
Results—Intrarater reliability was excellent for all 4 regions (intraclass correlation coefficient, >0.8). Interrater reliability was excellent for the centrum semiovale and hippocampus (intraclass correlation coefficient, >0.8) and good for the basal ganglia and mesencephalon (intraclass correlation coefficient, 0.6–0.8). This did not differ between the cohorts or experience levels.
Conclusions—We describe a reliable rating method that can facilitate pathogenic and prognostic research on dilated Virchow–Robin spaces using MRI.
- Received January 15, 2013.
- Revision received March 4, 2013.
- Accepted March 14, 2013.
- © 2013 American Heart Association, Inc.