Abstract 171: CRP, IL-18, and BNP are Associated with Regional Brain Atrophy: Results from the Dallas Heart Study
Purpose: Multiple biomarkers have been associated with total brain atrophy. However, little is known about their relationship to segmental atrophy in a large, multi-ethnic, population-based sample.
Materials and Methods: 3D-MPRAGE brain images obtained at 3T from 2082 participants of the Dallas Heart Study (DHS) 2 were analyzed with Freesurfer and outlier analysis was performed. Divisive eigenvalue clustering of 89 brain segments yielded 24 groups with linked atrophy patterns. Plasma C-reactive protein (CRP), IL-18, homocsysteine and B-type natriuretic peptide (BNP) obtained 7 years prior during DHS 1 were available for 1343, 840, 1333 and 1331 participants, respectively. Multivariate linear regression analysis with adjustments for age, ethnicity, and gender were used to demonstrate associations between biomarkers and atrophy clusters.
Results: Nine atrophy clusters were associated with CRP, three atrophy clusters were associated with IL-18, and six atrophy clusters were associated with BNP (Table 1). Homocysteine did not have any significant correlations.
Conclusions: The markers studied had associations with distinct patterns of segmental atrophy indicating they may have unique interactions in different brain regions. This suggests that distinct inflammatory and other pathways may be at work in specific regions of the brain and that their localized effects may be obscured by approaches evaluating solely total brain volumes. Table 1:
- © 2012 by American Heart Association, Inc.