Abstract TMP32: Clinical and Pathological Improvement in Stroke-Prone Spontaneous Hypertensive Rats Related to Pleiotropic Effect of Cilostazol
Background and Purpose: This study investigated the efficacy of anti-platelet drugs on stroke, and motor and cognitive functions in relation to oxidative stress markers and insulin-like growth factor 1 receptor (IGF-1R).
Methods: Stroke-prone spontaneously hypertensive rats (SHR-SP) were treated with vehicle, aspirin, clopidogrel and cilostazol from 8 to 10 weeks of age. Physiological parameters, regional cerebral blood flow (rCBF), motor and cognitive functions were evaluated. Spontaneous infarct volume, oxidative stress markers and the IGF-1R positive cell ratio in the hippocampus were immunohistochemically examined. IGF-1R expression in the hippocampus was assessed by western blotting.
Results: Cilostazol and clopidogrel reduced the spontaneous infarct volume more than aspirin. Only cilostazol improved motor and cognitive functions with a significant increase (p<0.05) in the memory-related IGF-1R positive ratio and IGF-1R expression in the hippocampus. Cilostazol reduced oxidative stress markers in affected neurons regardless of blood pressure or rCBF.
Conclusion: The present results suggest that a possible pleiotropic effect of cilostazol resulted in the reduction of spontaneous infarct volume and preservation of motor and cognitive functions. The increase of IGF-1R positive cells in the hippocampus could partly explain the preservation of cognitive function in SHR-SP.
- © 2012 by American Heart Association, Inc.