Abstract TP155: Do Gender Differences exist in Outcomes Among Patients With Intracranial atherosclerosis?
Background and purpose: Up to now gender difference in outcomes among patients with intracranial atherosclerosis (ICAS) in china, even in the world has rarely discussed. We went on this study aimed to estimate the gender difference in outcomes among patients with ICAS in Chinese cerebral ischemia patients.
Methods: We analyzed 1335 men and women with ICAS who were enrolled in the CICAS study. They were followed-up for ischemic stroke recurrence, any cause of death, cerebral vascular events (including TIA, ischemic and hemorrhage stroke), combined endpoints (including cerebral vascular events, angina or myocardial infarction, pulmonary embolism, peripheral vascular events), and unfavorable outcome (mRS 3-6) at 1 year.
Results: The mean ages were 60.9 (SD, 11.4) and 65.5 (SD, 10.2) for men and women. During the follow-up period, 59 combined end points were documented in women and 106 in men: the 1-year rates were 13.44% and 11.83% for women and men, respectively. Of the combined end points, 49 were recurrent ischemic stroke events (15 in women and 34 in men), and 48 any cause of deaths (23 in women 25 in men). There were 344 unfavorable end points (116 in women and 228 in men). The cumulative probability of death was higher in women, but after adjusted by age, diabetes mellitus, hypertension, family history of stroke, current smoker, heavy drink, hyperhomocystinemia, heart disease, there was no significant difference. There was also lack of difference in 1-year ischemic stroke recurrence, cerebral vascular events, combined endpoints and unfavorable outcome between women and men at 1 year.
Conclusions: These results suggest no gender difference in outcome among patients with intracranial atherosclerosis in Chinese cerebral ischemia patients.
- © 2012 by American Heart Association, Inc.