Abstract TP183: Cerebral Small Vessel Disease - A Population-based Cross-Ethnic Comparison between Chinese and White Elderly Individuals
Background and Purpose: Ethnic differences have been reported between Asians and Whites in the prevalence of certain stroke subtypes. However, it is unknown if such differences exist with respect to manifestations of cerebral small vessel disease. We compared the prevalence of white matter lesions [WML], lacunes, and microbleeds between Han Chinese and White Australian individuals randomly selected from their respective populations.
Methods: Magnetic resonance imaging (1.5 Tesla) was performed on participants of the Shanghai Aging Study (n=321, mean age 69±6 years) and Tasmanian Study of Cognition and Gait (n=397, mean age 72±7 years). A single expert rater recorded measures of WML, lacunes, and microbleeds. We compared lesion prevalence between age- and gender-matched subgroups from the two study population. Among all subjects (n=718), we used multivariable logistic regression to examine if ethnicity was associated with the presence of these lesions.
Results: The prevalence rates of confluent WML, lacunes, and microbleeds among Chinese and Whites were 37% vs. 34% (p=0.09), 29% vs. 34% (p=0.24), and 9% vs. 11% (p=0.59), respectively. Subgroup analysis among age- and gender- matched subjects confirmed that confluent WML was more common among Chinese (38.5%) than Whites (28.4%, p=0.01). In multivariable regression, Chinese had a higher risk of confluent WML (odds ratio 1.53, 95% confidence interval 1.04-2.24, p=0.03) independent of other risk factors, but no differences were seen for lacunes and micro bleeds.
Conclusion: In this population-based cross-national comparison, Chinese had a greater risk of moderate-to-severe WML than white Australians, but had a similar risk of lacunes and microbleeds.
- © 2012 by American Heart Association, Inc.