Abstract TP191: The Relationship Between Intracranial Atherosclerosis Assessed By Transcranial Doppler And Body Composition In Apparently Healthy Korean Adults
Background: Intracranial atherosclerosis is the cause for ischemic stroke and other cerebrovascular diseases. Transcranial Doppler (TCD) is a diagnostic modality that could be noninvasively used for the diagnosis of ischemic cerebral arteries. Body composition affects metabolic status and subsequently atherosclerosis. In this study, we analyzed the relationship between the intracranial atherosclerosis assessed by TCD and body composition in apparently healthy Korean adults.
Methods: TCD was performed to assess the status of cerebral arteries as a part of a health screening program. Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis trial methods was used to diagnose intracranial atherosclerosis with TCD. Body composition was assessed by bioelectrical impedance analysis method. Analyses were performed in 78 subjects with abnormal TCD finding and 150 age- and body mass index (BMI)-matched control subjects.
Results: Mean age of the participants was 49 years old. Mean BMI of the participants was 22.6 kg/m2. Although the age and BMI were matched in two groups, mean values of fasting glucose and systolic blood pressure were higher in abnormal group (94.5±14.5 vs. 99.3±18.3 mg/dL, 113.3±12.3 vs. 119.0±15.7 mmHg, P<0.05). When the components of body composition were compared between the two groups, abnormal group showed higher body fat ratio, lower lean body mass and higher waist-hip ratio (WHR) assessed by BIA method. When all the participants were analyzed divided in three groups according to the components of body composition, the proportion of subjects with intracranial atherosclerosis increased as the body fat ratio and WHR increased from 1st to 3rd tertile groups, and decreased as the lean body mass increased from 1st to 3rd tertile groups.
Conclusions: Subjects with intracranial atherosclerosis showed higher body fat and lower lean body mass. Subjects with high body fat and low lean body mass showed higher proportion of subjects with intracranial atherosclerosis.
- © 2012 by American Heart Association, Inc.