Abstract TP199: Association between Metabolic Syndrome and Carotid Atherosclerosis: a Community-based Study in Hong Kong
Background and Purpose— Carotid atherosclerosis is not neglectable as a cause for stroke in China, despite of low prevalence. This study was performed to evaluate the association between its ultrasonographic markers with metabolic syndrome (MetS).
Methods— This was a community-based cross-sectional study. Demographics, common vascular risk factors, and results of fasting blood analysis were collected at baseline. MetS was defined as ≥3 following conditions or receiving specific treatment: abdominal obesity, elevated triglycerides, low high-density lipoprotein cholesterol, hypertension and impaired fasting blood glucose. All subjects underwent carotid duplex ultrasonography. Mean carotid intima-media thickness (CIMT) of bilateral common carotid arteries was used as the CIMT value for a single subject. CIMT within the 4th quartile was regarded as increased CIMT. Carotid plaque was defined as a focal CIMT of >1.5 mm.
Results— A total of 653 subjects (mean age 55.1±10.4; 47.2% male) were recruited. MetS was found in 188 (28.8%) subjects (30.8% in male and 27.0% in female). Mean CIMT was 0.74±0.12 mm. Increased CIMT and carotid plaques were detected in 163 (25.0%) and 95 (14.5%) subjects, respectively. In multivariate linear regression, CIMT significantly increased with increasing numbers of MetS components (P<0.001). In multivariate logistic regression, MetS was independently associated with increased CIMT (OR 1.17; 95% CI 1.11-2.64; P=0.014) but not presence of carotid plaque (OR 1.50; 95% CI 0.92-2.46; P=0.108).
Conclusion— MetS may be independently associated with early stage but not later and advanced stages of carotid atherosclerosis in community residents in China.
- © 2012 by American Heart Association, Inc.