Abstract TP216: Cardio-Ankle Vascular Index (CAVI) Is A Novel Parameter To Predict Aortic Arch Plaque Causing Atherothrombotic Stroke
Aortic arch plaque is an important cause of atherothrombotic stroke. The cardio-ankle vascular index (CAVI) has been reported as a novel parameter for aortic stiffness, and high CAVI implies progression of carotid and coronary arteriosclerosis. However, it remains to be determined whether CAVI is associated with arch plaques.
We performed CAVI and transesophageal echocardiography in 290 subjects (197 males, 65 ± 12 years), including 29 patients with the history of atherothrombotic stroke. We defined arch plaque as wall thickness ≥ 4 mm and the presence of ulceration or mobile plaque in aortic arch.
CAVI showed a good correlation with age, systolic blood pressure, fibrinogen, von Willebrand factor, carotid plaque score and arch wall thickness. CAVI was higher in subjects with following risk factors than in those without; hypertension, diabetes mellitus, and dyslipidemia. CAVI was higher in subjects with ulceration or mobile plaques than in those without. CAVI was higher in subjects with atherothrombotic stroke than in those without (10.5 vs. 8.6, P<0.001). The subjects with CAVI ≥ 9 had higher risk for atherothrombotic stroke compared with those with CAVI < 9 in univariate logistic regression analysis (odds ratio 5.07, 95% confidence interval 2.16-11.91). Multivariate logistic regression analysis revealed that CAVI was an independent risk factor for atherothrombotic stroke.
In conclusion, CAVI is a novel parameter predicting aortic arch plaques, which cause atherothrombotic stroke.
- © 2012 by American Heart Association, Inc.