Abstract TP302: Brain Natriuretic Peptide Upon Admission Should Predict Patients Mortality Within 1 Year After Onset Of Intracerebral Hemorrhage
Background and Purpose: A recent study demonstrated that the plasma level of BNP is an independent predictor of long-term mortality after ischemic stroke. Furthermore, BNP also increases in patients with acute intracerebral hemorrhage (ICH). However, the relationship between BNP and long-term mortality after ICH is not clear. We investigated the relationship between BNP and mortality within 1 year after onset of ICH.
Methods: We prospectively enrolled ICH patients who were admitted within 24 hours of onset from April 2007 to December 2010 and measured plasma BNP upon admission. Follow up was performed at 12 month from enrollment and patients were divided into two groups: the survival group and the death group. The factors associated with mortality were determined by multiple logistic regression analysis.
Results: A total of 304 patients ( median age, 72 years , 112 female) were enrolled in the present study. The locations of the hematoma were: the putamen in 102 (34%)patients, the thalamus in 93 (30%), the lobar in 40 (13%), the brainstem in 28 (9%), the cerebellum in 20 (7%), and other location in 21 (7%). 86 patients (28%) died during 12 month from enrollment. The mean±SD admission BNP level for all patients was 123.1±320.8 pg/ml. The median of age, NIHSS score on admission, frequency of preadmission warfarin use, preadmission antiplatelet use, a past history of diabetes mellitus, atrial fibrillation, ICH, coronary artery disease, hemoglobin, glucose level, ICH volume and BNP level were significantly higher in the death group than in the survival group. In multivariate logistic regression analysis, age >71years (odds ratio [OR], 2.3; 95%CI, 1.080-5.054, P=0.03112), NIHSS score on admission >16 (OR, 2.9; 95%CI, 1.407-6.053, P=0.00400), past history of diabetes mellitus (OR, 2.5; 95%CI, 1.139-5.567, P=0.02246), glucose level >145 mg/dl (OR, 2.0; 95%CI, 1.005-4.136, P=0.04831), ICH volume >10 cc (OR, 4.1; 95%CI, 1.963-8.503, P=0.00017), and a plasma BNP level >50 pg/ml (OR, 2.9; 95%CI, 1.457-5.931, P=0.00260) were found to be independently associated with mortality within 1 year after onset.
Conclusions: BNP level (>50 pg/ml) upon admission should predict patients mortality within 1 year after onset of ICH.
- © 2012 by American Heart Association, Inc.