Abstract TP312: Longitudinal Functional Connectivity Change Associated With Rehabilitation Training In Sub-acute Stroke Patients
Background and aims: The neural correlate of the motor recovery associated with different rehabilitation therapy is still unknown in stroke patients. In this study, the resting-state fMRI was employed to identify longitudinal functional connectivity changes associated with different rehabilitation training in sub-acute stroke patients.
Methods: Twenty-four sub-acute ischemic stroke patients with right-handed were recruited from Beijing Tiantan Hospital, all of the patients had unilateral upper limb paresis. The subjects were randomly divided into conventional rehabilitation training (CRT) group and functional electrical stimulation (FES) training group. The motor function assessments included FMA, ARAT and MAS. Resting-state fMRI scan were acquired on a Siemens 3.0 T scanner at pre-training and post-training. Ipsilesional primary motor cortex (M1) was selected as the region of interest (ROI), then the functional connectivity (FC) with ipsilesional M1 were analyzed respectively for the two groups.
Results: Compared with CRT group, the motor function assessments showed that each motor index increased significantly in FES group. For CRT group, compared with pre-training, we found that the FC of ipsilesional M1 increased with the contralesional cerebellum crus I&II, medial and inferior temporal gyrus at post-training . On the contrary, for FES group, compared with pre-training, FC of ipsilesional M1 decreased with the contralesional cerebellum crus I&II, medial and inferior temporal gyrus at post-training .
Conclusion: The different pattern of the longitudinal changes of functional connectivity might contribute to the motor recovery with different rehabilitation training.
- © 2012 by American Heart Association, Inc.