Abstract TP440: The Discriminant Validity of the NINDS-CSN Harmonization Neurocognitive Battery in Detecting VCI in Singaporean Patients with Ischemic Stroke and TIA
Background: An international standard for the diagnosis of Vascular Cognitive Impairment (VCI) is currently in development. We report preliminary findings of Singaporean contribution to theNINDS-Canadian Stroke Network (NINDS-CSN) neuropsychological protocol harmonization study.
Purpose: We examined the discriminant validity of 3 neuropsychological protocols (60 Minute (M), 30M and 5M) by comparing cognitive performance of patients with stroke and TIA to cognitively normal controls.
Methods: Patients (≥50 years old) with stroke or TIA and the controls were administered the NINDS-CSN harmonization neurocognitive battery by trained psychometricians blinded to the group status of the patients or controls. ANCOVA was conducted to compare the between group cognitive performance. ROC analyses were employed to examine the ability of the 3 protocols and the cognitive domains of the 60M protocol in discriminating patients with ischemic stroke or TIA from the controls.
Results: 52 patients and 64 controls were recruited. Patients were significantly older with lower level education and more self-reported depressive symptoms than the controls (mean age 67.7±9.2 vs 62.2±6.7, p<.001; years of education: 6.5±4.6 vs 11.5±4.1, p<.001; Geriatric Depression Scale: 3.0±3.7 vs 1.0±1.0, p<.01). Using age, education and GDS as covariates, ANCOVA showed that the performance of stroke and TIA group were significantly poorer than controls on the 5-min, 30-min and 60-min protocols (F statistics range from 7.1 to 38.7, p<.01). ROC analyses showed adequate discriminatory abilities of these 3 protocols (AUCs range from 0.80 to 0.84). Executive function and memory domains of the 60M protocol were two most sensitive and specific domains in discriminating patients with stroke and TIA from the controls (AUCs: 0.87, 0.81, respectively).
Conclusions: The results demonstrated preliminary evidence for the validity of the NINDS-CSN neurocognitive battery in discriminating patients with ischemic stroke and TIA from cognitively normal controls.
- © 2012 by American Heart Association, Inc.