Abstract WMP15: Hemispheric Asymmetry of Frontoparietal Control Network in Acute Ischemic Stroke Correlates with Stroke Severity
Introduction: Recent resting-state fMRI (rsfMRI) studies revealed a frontoparietal control (FPC) network specialized in cognitive control and decision-making. In this study, we hypothesize that acute hemispheric asymmetry of functional connectivity within the FPC network predicts clinical severity and long-term functional outcome.
Methods: RsMRI was performed in nine ischemic stroke patients (mean age: 75.33 ± 7.6 y; 6 male; 7 MCA, 2 ACA affection) within 3 hrs after onset. NIH Stroke Scale was obtained at admission, 24 hours and 72 hours after symptom onset. Modified Rankin Scale (mRS) was obtained 1 month after onset. FPC network was defined using a seed-based approach (ipsilesional hemisphere seed) and thresholded at the 95th percentile. FPC asymmetry index was defined as the absolute difference of the proportion of voxels within the network between the two hemispheres. Linear partial correlations were calculated between FPC asymmetry index and clinical scores controlling for NIHSS at admission (significance: P < 0.05).
Results: Asymmetry index of the FPC network showed a significant positive correlation with NIHSS at 24 hours (R2=0.5113, P=0.0462), 72 hours (R2=0.5406, P=0.0376) and marginally significant correlation with MRS at 1 month (R2=0.2799, P=0.1775).
Conclusions: Significant correlations between FPC asymmetry index and subsequent clinical assessments suggest that the integrity of FPC network during acute ischemia may impact stroke recovery. Acute functional connectivity measurements pertaining to the high order, FPC network, may have potential for early prediction of outcomes in acute ischemic stroke.
- © 2012 by American Heart Association, Inc.