Abstract WMP74: Plasma Interleukin-6 Values Are Associated With Neurological Severity In Ischemic Stroke
Introduction: Interleukin-6 (IL-6) is a representative pro-inflammatory cytokine produced by various cells; however, it also plays multi-functional roles besides the immune function. Although several studies have shown that IL-6 levels are increased after stroke, its significance in stroke remains still controversial. We aimed to examine the temporal profile of plasma IL-6 after stroke and to investigate its significance in neurological severity. We tested the hypothesis that plasma IL-6 is associated with neurological severity in ischemic stroke patients.
Methods: We prospectively enrolled 171 patients with ischemic stroke and age- and gender-matched healthy controls. Blood samples and clinical information were obtained at five time points (days 0, 3, 7, 14 and 90) after stroke onset.
Results: Average IL-6 values at day 0 were significantly higher in the stroke patients than in the controls (6.3 ± 1.5 pg/mL vs. 1.2 ± 0.1 pg/mL, p = 0.0005). In the patients, IL-6 values at day 0 was positively associated with neurological severity as evaluated by National Institute of Health Stroke Scale (NIHSS) (r = 1.3292, p < 0.0001). When the patients were divided into 4 groups (Q1, Q2, Q3 and Q4 from milder to severer group) according to the interquartile range of the NIHSS on admission, Q1 (3.0 ± 1.1 pg/mL, p = 0.0075), Q2 (2.4 ± 0.6 pg/mL, p = 0.0033), Q3 (3.2 ± 0.7 pg/mL, p < 0.0001) and Q4 (17.9 ± 5.7 pg/mL, p < 0.0001) groups had significantly higher IL-6 values than the controls. IL-6 values reached the maximum at the day 3 after stroke and decreased subsequently, although they were significantly higher than those of the controls at all the 5 points (Figure). IL-6 values were significantly higher (11.0 ± 3.1 pg/mL vs. 2.7 ± 0.7 pg/mL, p = 0.0065) in the poor outcome group (modified Rankin Scale (mRS) ≥ 2 at 90 day) than the good outcome group (mRS ≤ 1).
Conclusions: Plasma IL-6 is increased with the maximum at day 3 after ischemic stroke and is associated with neurological severity.
- © 2012 by American Heart Association, Inc.