Abstract WMP90: Homozygous Short Variation Allele Genotype of the Serotonin-Transporter-Linked Polymporphic Region (5-HTTLPR) is Associated Post-Sstroke Depression- A Meta-analysis
Aim: Polymorphisms of the genes for encoding serotonin transporter, specifically, the length variation in the serotonin-transporter-linked polymorphic region (5-HTTLPR), a single nucleotide polymorphisms, in the 5-HTTLPR (RS25531), and variable number of tandem repeats (VNTR) in the second intron 2 (STin2) have been implicated in the development of post-stroke depression (PSD). We aimed at evaluating this association in the published literature.
Methods: Random-effects meta-analyses were conducted among studies examining the relations between the polymorphisms of the genes encoding serotonin transporter and the risk of developing PSD. Meta-regression identified patient- and study-related factors that may contribute to heterogeneity.
Results: Five studies consisting of patients suffering from PSD and stroke patients without PSD were included. Our analyses showed statistically significant evidence of the positive association between the homozygous short (S) variation allele genotype of the 5-HTTLPR (SS) and PSD (random-effects pooled odds ratio (OR) = 2.05, 95% Confidence Interval (CI) = 1.41-2.98, Z =3.79, p< 0.001 ). Our analyses also showed significant evidence of a negative association between the homozygous long (L) variation alleles of the 5-HTTLPR (LL) and PSD (random-effects OR = 0.52, 95% CI = 0.27-0.97, Z =- 2.07, p= 0.039). No statistically significant association of PSD with either heterozygous Short and Long allele genotype for the 5-HTTLPR or other polymorphisms with the RS25531 and the STin2 VNTR were found.
Conclusion: Our meta-analysis suggests that the 5-HTTLPR SS genotype may be a risk factor for PSD while the 5-HTTLPR LL genotype may be a candidate protective factor against PSD
- © 2012 by American Heart Association, Inc.