Abstract WP18: Gender Differences In Intra-arterial Therapy
Background: Women have higher post-stroke mortality and rate of disability. Earlier studies have reported on difference between outcomes in men and women with regard to CEA, stenting and tPA. However, there are no studies comparing gender differences with intra-arterial (IA) treatment in patients with symptomatic intracranial stenosis.
Methods: This retrospective study performed at an academic tertiary care facility compared men and women treated for M1 severe stenosis or occlusion with IA therapy from November 2002 to May 2011. We compared baseline premorbid conditions. Treatment outcomes included infarct size, modified Rankin Scale (mRS) and mortality. Two-tailed Fischer’s Exact Test was used for data analysis.
Results: Of 223 patients, 105 (47.1%) were men and 113 (50.7%) were women. Women were older (64.1 vs. 67.9 years; p < 0.05). Baseline characteristics such as hypertension, atrial fibrillation and hyperlipidemia showed no significant differences between men and women (p> 0.05). NIHSS at presentation (15.5 vs 16.1; p > 0.05) and infarct size post intervention (78.6 vs 76.5 cc3; p > 0.05) were not different. Successful revascularization rate was 88% in women and 81% in men (p = 0.15). 56% of men but only 41% of women had a mRS ≤ 2 at 3 months. (p < 0.05). Preliminary data suggests no differences in mortality.
Conclusion: Despite the findings that infarct size and revascularization rates were the same between men and women, women had worse functional outcomes at 3 months. In future investigations, we will identify contributing factors that may explain outcome differences between men and women.
- © 2012 by American Heart Association, Inc.