Abstract WP202: The Metabolic Syndrome Significantly Increases the Risk of Ischemic Stroke in the Mexican Hispanic Population
Background and Purpose: Stroke is a major health burden in the United States in both morbidity and mortality. Evidence showed that the Hispanic population is disproportionately affected by this condition, while the prevalence of diabetes, hypertension, dyslipidemia and obesity is coincidently on the rise in the same group. We hypothesized that these factors, known as the Metabolic Syndrome, significantly increase the risk of ischemic stroke in Hispanic population.
Methods: To test our hypothesis, we used data from ElPasoStroke (n=505) which were created in a retrospective study conducted in El Paso, TX, USA, and matching subjective data from the NHANES database (n=1010) to assess the effects of Metabolic Syndrome risk factors on the pathogenesis of ischemic stroke among the Mexican Hispanic population. Subjects were classified as obese if BMI ≥ 30, and as having the metabolic syndrome if they had three or more of: obesity, diabetes, hypertension, and dyslipidemia. Odds ratios (OR) and 95% confidence interval (CI) between different groups and age stratified groups were calculated for the evaluation of pathogenic effects of individual components of metabolic syndrome, as well as other risk factors for stroke.
Results and Conclusion: Our results show that the metabolic syndrome substantially increases the odds of suffering ischemic stroke among the Mexican Hispanic population, with the risk being greatest in the younger age groups. Hypertension alone has the most significant impact, putting Hispanics at nearly forty times the risk of suffering stroke (Table 1). In conclusion, the metabolic syndrome significantly increases the risk of ischemic stroke in the Mexican Hispanic population, and efforts to prevent stroke incidence ought to be directed at reducing the prevalence of the metabolic syndrome in this population.
- © 2012 by American Heart Association, Inc.