Abstract WP368: Differences In Antioxidant Capacity, Oxidative Stress, And Nutrient Intake Patterns Between Male And Female Stroke Patients.
Background and aims: Oxidative stress may be related to the pathogenesis of stroke. It has been suggested that there is a gender difference in oxidative stress and antioxidant capacity. The present study was conducted to elucidate differences in antioxidant capacity and related factors to antioxidant capacity between the male and female patients one year post-stroke.
Methods: A total of 189 ischemic stroke patients who were admitted to Asan Medical Center were screened. Blood samples were collected for ferric reducing ability of plasma (FRAP) for antioxidant capacity, thibarbituric acid reactive substance (TBARS) for oxidative stress at one year post stroke. Anthropometric measurements were also obtained to determine nutritional status. Dietary intakes of the patients were obtained for 2 days by 24 hour dietary recall method and were analyzed with CAN pro (3.0 version). National institutes of health stroke scale (NIHSS), barthel index (BI), and the presence of depression (Beck Depression Inventory, BDI) were also investigated.
Results: There were 123 (65.1%) male and 66 (34.9%) female patients. No differences were found in stroke subtype, age, and body mass index (BMI) between the groups, while economic status (p=.014), employment status (p<.001), current smoking (p<.001) and alcohol intakes (p<.001) were higher in male than in female patients. The male also had higher FRAP level (p=.001), lower NIHSS (p=.024), higher BI (p=.031), and lower BDI score (p=.042) than the female whereas no difference was found in TBARS. Regarding dietary intakes, protein (p<.001), lipid (p<.001), dietary fiber (p<.001), Vit. A (p=.011), Vit. B6 (p<.001), and folate(p=.030) intakes were higher in the male group than the female group. In multivariate analysis, drinking (p=.003) was the predicting factor in the male whereas high BMI(p=.019) was the predicting factor of FRAP in the female group.
Conclusion: Antioxidant capacity was higher in the male than in the female one year post-stroke. Special attention should be paid to female stroke patients since they have low antioxidant capacity with low intakes of antioxidant nutrients.
- © 2012 by American Heart Association, Inc.