Abstract WP416: Risk Factors for Symmetrical Distribution of Carotid Atherosclerotic High-risk Plaque Determined by Black-blood, High Resolution Magnetic Resonance Imaging
INTRODUCTION: Control of risk factors that are associated with carotid high-risk plaques will play important role in plaque stabilization and prevention of ischemic events. However, the relationship between traditional risk factors and carotid high-risk plaques is unclear. This study sought to determine the risk factors that are associated with carotid high-risk plaques.
Methods: Eighty-one patients (mean age 61 years, 60 males) with recent ischemic stroke and carotid plaque on ultrasound underwent MR imaging using multicontrast sequences (T1W, T2W, 3D TOF, and MP-RAGE). The clinical risk factors, such as age, gender, hypertension, diabetes, current smoking, blood pressure, pulse pressure (PP), BMI, and cholesterol levels were collected. The presence/absence and the maximum percentage of carotid lipid-rich necrotic core (LRNC) and intaplaque hemorrhage (IPH) to wall area for each artery were determined. Lesions with either IPH or large LRNC (% LRNC ≥20%) were defined as high-risk. The patients were divided into three groups according to the symmetrical distribution of carotid LRNC or IPH at none, unilateral, and bilateral carotid arteries. The risk factors in three different groups were compared.
Results: Of 81 patients, 71.6%, 18.5%, and 9.9% had none, unilateral, and bilateral IPH at carotid arteries, respectively. We also found that 54.3%, 27.2%, and 18.5% of patients had none, unilateral, and bilateral large carotid LRNC, respectively. There was significant difference in BMI and PP among three groups of patients with none, unilateral, and bilateral carotid IPH or large LRNC (all P<0.05) (Fig. 1A-B).
Conclusions: BMI and pulse pressure are associated with symmetrical disrtibution of carotid high-risk plaque indicating that control of these risk factors might be helpful for plaque stabilization.
- © 2012 by American Heart Association, Inc.