Abstract WP417: Ideal Cardiovascular Health Metrics on Risk of Ischemic and Intracerebral Hemorrhagic Stroke: A Result from Kailuan Study
Objectives To investigate the relationship between ideal cardiovascular health metrics (including smoking, body mass index, dietary intake, physical activity, blood pressure, total cholesterol and fasting blood glucose) and risk of stroke.
Background Previous studies showed a strong relationship between the number of ideal cardiovascular health metrics and lower risk of cardiovascular diseases and stroke. However, little is known regarding its relationship with ischemic and hemorrhagic stroke risk respectively.
Methods We collected information on the ideal cardiovascular health metrics among 91,698 participants (18-98 years old; 72826 men and 18872 women) free of myocardial infarction and stroke at baseline (2006-07) in the Kailuan cohort study, China. We then prospectively investigated the association between ideal cardiovascular health metrics and risk of stroke.
Results During four years of follow-up, we identified 1443 incident strokes (1057 ischemic and 386 intracerebral hemorrhagic). The multivariate-adjusted hazard ratios for total stroke with adherence to 0 (reference), 1, 2, 3, 4, 5, and 6 or 7 ideal health metrics were 1, 0.91, 0.69, 0.51, 0.37, 0.28, and 0.25 (95% confidence interval: 0.11-0.55; p-trend <0.0001) respectively after adjusting for age, sex, and other covariates. Similar inverse associations were observed for both ischemic and intracerebral hemorrhagic stroke (p-trend < 0.0005 for both).
Conclusions We observed a clear inverse dose-response relationship between the number of ideal cardiovascular health metrics and risk of stroke in a Chinese population, which supports the importance of ideal health behaviors and factors in the prevention of stroke.
- © 2012 by American Heart Association, Inc.