Stroke Literature Synopses: Basic Science
Optogenetics is the combinational method of optical and genetic approaches, which allows us to control neuronal activities in a quick and precise manner. This technique was selected as the Method of the Year in 2010 by Nature Medicine, and although relatively new, has already been used to reveal many novel mechanisms of how the brain works. Three recent optogenetics articles showcase the use of this powerful approach for dissecting stroke pathophysiology.
Anenberg et al (Ministrokes in channelrhodopsin-2 transgenic mice reveal widespread deficits in motor output despite maintenance of cortical neuronal excitability. J Neurosci. 2014;34: 1094–1104) combined optogenetics and electrophysiological approaches to show that there is a mismatch between measures of cortical excitability and motor output within 60 minutes after stroke …