Stroke Literature Synopses: Basic Science
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Stroke is a multifactorial disease. Hence, potential therapeutic approaches can be found in multiple compartments and mechanisms. Three recent studies describe how new targets may be dissected in terms of preventing neuron death, ameliorating inflammation, and modifying thrombosis.
Irmady et al (MiR-592 regulates the induction and cell death–promoting activity of p75NTR in neuronal ischemic injury. J Neurosci. 2014;34:3419–3428) proposed that miR-592/p75NTR would be a therapeutic candidate to protect neurons from apoptosis after ischemic injury. p75NTR is a member of the tumor necrosis factor receptor superfamily, and this study showed that p75NTR expression increased after ischemic stress both in vivo and in vitro (eg, mouse brains in a focal ischemia model and cultured hippocampal slice or neurons after oxygen–glucose deprivation). Delivery of function-blocking antibodies for p75NTR reduced neuronal apoptosis in vitro, and furthermore, infarct volume by middle cerebral …