Abstract 155: Health-Related Quality of Life in Patients With Unruptured Brain Avm Managed With or Without Interventional Therapy - The Aruba Trial
Background: Only limited data are available on self-reported Health-related Quality of Life (HRQoL) in patients harboring an unruptured brain arteriovenous malformation (bAVM). Also, the effect of interventional therapy on HRQoL has not been systematically studied.
Methods: Of the 223 prospective patients enrolled in ARUBA (A Randomized trial of bAVMs), 114 were allocated to medical management plus interventional therapy (IT), while 109 allocated to medical management alone (MM). During prospective follow-up, HRQoL parameters were systematically measured using the EuroQoL EQ-5D health questionnaire.
Results: After 24 months of follow-up, EQ-5D data were available on 112 patients (53 IT, 59 MM). Compared to IT, those allocated to MM reported on significantly fewer problems with mobility (18.6% vs. 37.7; RR 0.49, 95CI 0.26-0.93), self-care (1.7 vs. 17.0%; RR 0.10, 95%CI 0.01-0.76), and usual activities (27.1% vs. 43.4%; RR 0.62 95%CI 0.37-1.05), but suffered more frequently from anxiety and/or depression (47.5 vs. 24.5; RR 1.93, 95%CI 1.12-3.33). No difference was found for pain or discomfort, nor for overall health state on the EuroQoL visual analog scale.
Conclusion: For patients with unruptured bAVM who are followed medically over 24 months, clinical self-assessments using the EuroQoL EQ-5D health questionnaire confirms a lower risk of clinical impairment as compared to those undergoing therapeutic interventions. The risk of self-reported anxiety and/or depression, however, seems to be higher in patients living with an untreated bAVM.
Author Disclosures: C. Stapf: Research Grant; Significant; NINDS U01NS051483. C.S. Moy: None. J. Overbey: None. E. Moquete: None. M. Parides: Other Research Support; Significant; NINDS U01 NS051566. E. Vicaut: Research Grant; Significant; NINDS U01NS051483. A.J. Moskowitz: Research Grant; Significant; NINDS U01NS051566. J.P. Mohr: Research Grant; Significant; U01NS051483.
- © 2014 by American Heart Association, Inc.