Abstract 2: Extensive Collateral Recruitment after Intravenous Thrombolysis in Acute Ischemic Stroke is Associated with Symptomatic Intracranial Haemorrhage
Background: Various collateral channels are recruited to provide alternative pathways in acute ischemic stroke (AIS), however the relationship with patient outcomes remain unclear. We compared various existing methods of scoring collaterals on the pre-treatment and day-2 computed tomographic angiogram (CTA) of the brain in thrombolyzed AIS patients.
Methods: We included 115 consecutive patients in whom CTA was performed both pre-tPA and on day-2. Intracranial collaterals were evaluated by 2 independent neuroradiologists using 4 existing and one modified method- Miteff’s system (grades middle cerebral artery (MCA) collateral branches with respect to sylvian fissure); Maas system (compares collaterals in affected hemisphere against the contralatral side); Modified Tan’s scale (collaterals in 50% or more of MCA territory classified as good); and 20-point collateral grading scale by Alberta Stroke Program Early CT score (ASPECTS) methodology. For the modified scoring system we adapted ASPECTS methodology into a 14 point score for cortical and internal cerebral veins (ICV) and removing basal ganglia area from scoring. Symptomatic intracranial hemorrhage (SICH) was defined by new bleeding on the CT scan and an increase in NIH stroke scale (NIHSS) by 4 points or more.
Results: On univariate analysis collateral recruitment via the Tan scoring system, ASPECTS method (improvement of ≥6 points), modified scoring system (improvement ≥7 points), hypertension and higher NIHSS score were associated with SICH. On multivariate analysis only collateral recruitment on the Tan scoring system (OR 3.286 95% CI 1.014-11.025, p =0.049), Collateral recruitment on ASPECTS ≥6 points (OR 2.839 95% CI 1.064- 7.576, p = 0.037) and collateral recruitment on the modified scoring system ≥ 7 (OR 4.174 95% CI 1.212-14.372, p = 0.023) were independent predictors of SICH. Interestingly, collateral failure on the day-2 CTA did not show any association with SICH.
Conclusion: Large recruitment of the collateral channels on the day-2 CTA is strongly associated with SICH after thrombolysis . Perhaps, an unregulated cerebral hyperperfusion contributed to SICH and close monitoring along with aggressive blood pressure control might prevent complications.
Author Disclosures: L. yeo: None. P. Paliwal: None. H. Teoh: None. R.C.S. Seet: None. B.P.L. Chan: None. R. Rathakrishnan: None. K.W.P. Ng: None. C. Bharatendu: None. A. Batra: None. B. wakerley: None. J. ong: None. V.H.L. Ong: None. G.H.T. Lim: None. E.Y.S. Ting: None. V. Sharma: None.
- © 2014 by American Heart Association, Inc.