Abstract 45: Carotid Intima-Media Thickness is Associated with White Matter Hyperintensity Volume: The Northern Manhattan Study
Background: White matter hyperintensities (WMH) have been associated with increased risk of stroke, cognitive impairment and dementia. WMH may be a manifestation of small vessel disease although their pathophysiology remains unknown. We sought to evaluate the relationship between carotid intima-media thickness (cIMT), a subclinical ultrasound imaging marker of vascular disease, and WMH measured from brain MRI in a multi-ethnic, stroke-free community-based cohort.
Methods: As a part of population based Northern Manhattan Study, we evaluated a group of stroke and myocardial infarction - free individuals who had brain MRI and high-resolution carotid ultrasound performed. We used linear and logistic regression to examine the effect of continuous measures of cIMT on quantitatively derived WMH volume (WMHV) while adjusting for age, sex, race-ethnicity, hypertension or diastolic blood pressure, diabetes, body-mass index, plasma total cholesterol, LDL, HDL, and a history of smoking.
Results: Among 1140 participants (mean age: 70.6±9.0, 61% women, 15% White, 16% Black, 59% Hispanics) the mean cIMT was 0.89 ± 0.14mm and WMHV 0.68 ± 0.84. In a multivariable linear model, increase in log-cIMT was significantly associated with increase in log-WMHV (β=0.41, p=0.0018).
Conclusion: Increased cIMT may be a marker of increased WMHV independent of demographics and traditional vascular risk factors, contributing to the vascular mechanism of white matter disease. Therefore, carotid ultrasound may be an effective tool for assessing the risk of increased white matter disease in its pre-clinical stage.
Author Disclosures: M.S. Markert: None. C. Dong: None. D. Della-Morte: None. E. Roberts: None. S. Bartels: None. R.L. Sacco: None. M.S.V. Elkind: None. C.B. Wright: None. T. Rundek: None.
- © 2014 by American Heart Association, Inc.