Abstract T MP48: Determinants of Early and Late Recovery After Acute Ischemic Stroke: A Multicenter Stroke Registry-based Observational Study
Background: Recovery after acute ischemic stroke is usually bi-phasic. It begins early with speed and slows down after the first month. Many factors have been reported as determinants of functional outcomes. However, there is a paucity of information on their differential effects on early and late recovery.
Methods: Using a multicenter prospective stroke registry database, we identified ischemic stroke patients who were hospitalized within 7 days of onset to 12 hospitals, who were discharged within 30 days. Early recovery was defined as improvement of ≥ 4 points or > 50% in the NIH Stroke Scale (NIHSS) scores between baseline and discharge, and late recovery was as improvement of ≥ 1 point in mRS scores between discharge and 3 months. Multivariate logistic regression analysis was performed to estimate effects of independent variables considering a correlation between the two dependent variables, early and late recovery.
Results: During 54 months, 11088 patients met the eligibility criteria. Early recovery was observed in 36% and median NIHSS change from baseline to discharge was 3 points. Late recovery was found in 33%. Multivariate analysis for revealed that 1) age, pre-stroke mRS, initial NIHSS and prior statin use were associated with both the early and late recovery, 2) onset to arrival time, large artery atherosclerosis, previous stroke, initial blood glucose level, congestive heart failure, thrombolytic treatment were with the early recovery only, and 3) cardioembolism and statin at discharge were with the late recovery only (p’s<0.05). Tests for estimating equality showed that age, onset to arrival time, initial NIHSS, initial blood glucose level, systolic blood pressure, smoking, thrombolytic treatment had differential effects on early and late recovery (p’s<0.05).
Conclusion: Many of known determinants of 3-month functional outcome may have differential effects on early and late recovery of acute ischemic stroke.
Author Disclosures: M. Jang: None. J. Kang: None. B. Kim: None. J. Hong: None. M. Yeo: None. M. Han: None. B. Lee: None. K. Yu: None. Y. Cho: None. K. Hong: None. J. Park: None. K. Kang: None. J. Cha: None. D. Kim: None. J. Ahn: None. T. Park: None. K. Lee: None. S. Lee: None. Y. Ko: None. J. Lee: None. J. Kim: None. D. Kim: None. J. Choi: None. J. Lee: None. J. Lee: None. H. Bae: None.
- © 2014 by American Heart Association, Inc.