Abstract T P105: Cognitive Impairment is Common After Both Lacunar and Non-Lacunar Stroke and Persists at One Year
Background: Few data exist on long term cognitive outcome after lacunar stroke. We assessed cognition 1-6 weeks and 1 year after lacunar and mild cortical stroke, whilst correcting for age, SVD, depression and pre-morbid IQ.
Methods: We recruited consecutive patients with lacunar and mild cortical stroke, diagnosed with DWI-MRI and careful clinical assessment. At 4-6 weeks and 1 year after index stroke we assessed white matter hyperintensities (WMH; Fazekas scale), cognition (Addenbrookes Cognitive Assessment, ACE-R), pre-morbid IQ (National Adult Reading Test, NART) and depression (Beck Depression Index, BDI). We defined 'dementia' as an ACE-R<88.
Results: At 4-6 weeks post-stroke, 61/157 (38%) had dementia; at 1 year 56/151 (37%) had dementia; 136 were tested twice. Of the 45 who had dementia at first assessment & 9(20%) no longer had dementia at 1 year; of the 91 who did not have dementia at 4-6 weeks, 13 (14%) had become demented by 1 year. Patients with lacunar stroke had similar risk of cognitive impairment as patients with cortical stroke when adjusted for age, Fazekas score, BDI and NART in multivariable analyses (OR 0.91, 95%CI 0.32-2.13 at 1st assessment & 0.81, 95%CI 0.46-2.27 at 1 year). Previous stroke, low pre-morbid IQ and depression increased risk of dementia at both time points, but not vascular risk factors, sex, NIHSS or Fazekas score.
Conclusion: Over one third of patients with a non-disabling stroke had dementia at 4-6 weeks post stroke, most of these (80%) remained demented at one year and 13% of those who were cognitively intact ay 4-6 weeks developed dementia by 1 year. Patients with lacunar stroke are equally likely to have dementia as those with cortical stroke, despite the small lesion size and good prognosis. Low pre-morbid IQ increases dementia risk. Future research should account for pre-morbid IQ, age and depression.
Author Disclosures: S. Makin: None. M.S. Dennis: Research Grant; Significant; NIHR (UK) 08/14/03 2010-2014. Other Research Support; Modest; Covidien, provided materials for an RCT of which I am a PI from 2001-present. J.M. Wardlaw: Research Grant; Significant; Welcome Trust.
- © 2014 by American Heart Association, Inc.