Abstract T P126: Cerebral Microbleeds and Functional Outcomes at Discharge and 6 Months after Acute Ischemic Stroke
Introduction: Whether preexisting cerebral microbleeds (CMB) are associated with poor functional outcome after ischemic stroke has not been reported before. We examined the associations between CMB and functional outcome at discharge and 6 months after ischemic stroke.
Method: We studied 207 consecutive patients with acute ischemic stroke within 1 week after symptom onset who admitted to our hospital for 1 year. Assessment of stroke severity (by NIHSS) was made at the time of admission, at 24 hours after admission, at discharge and 6 months after admission. Functional outcomes (by modified Rankin scale) were evaluated at discharge and 6 months after admission. Patients’ outcomes were dichotomized into good and poor functional outcome groups with the mRS score cutoff 1 (no significant disability)/2 (slight disability). Microbleeds of each patient were analyzed by an experienced neuroradiologist. Demographic and clinical characteristics, the presence of CMB were compared between two groups. Then, logistic multivariable regression analysis was performed including all variables with a probability value <0.2 in the univariate analysis.
Results: More patients with poor functional outcome had CMB (45.6% vs. 27.4%; p=0.008) and they had more number of CMB (2.8±5.7 vs. 1.3±4.0; p=0.034) compared with patients with good functional outcome.
After multivariable regression analysis, there were no independent associations between CMB and functional outcome with adjustment for age, sex, history of diabetes, WMH and initial scores on NIHSS at discharge.
At 6 months after ischemic stroke, CMB were significantly associated with poor functional outcomes after adjustment for age, history of previous stroke and hypertension, WMH and initial scores on NIHSS (OR 2.1 95% CI: 1.0-4.5, p= 0.046). When patients were subdivided into those with lobar CMB and those with deep or infratentorial CMB, we found significant association between infratentorial CMB and poor functional outcome (OR 3.8 95% CI: 1.4-10.4, p= 0.009) and an associated trend between lobar CMB and poor outcome (OR 2.1 95% CI: 0.9-4.7, p= 0.067).
Conclusion: CMB, especially infratentorial area, were significantly associated with worse functional outcomes at 6 months after stroke.
Author Disclosures: T. Kim: None. J. Koo: None. J. kim: None. H. Choi: None. K. Lee: None.
- © 2014 by American Heart Association, Inc.