Abstract T P159: Cardiovascular Health and Subsequent Cognitive Function in Patients with Pre-existing Coronary Heart Disease.
Background: Cardiovascular (CV) health factors are associated with lower risk of CV disease, stroke and all-cause mortality. We used a CV health metric in order to examine association with subsequent cognitive function.
Methods: A subset of patients with coronary heart disease (CHD) that participated in the secondary prevention BIP trial were assessed for cognitive function (Mindstream Computerized Cognitive Battery) after an average of 9.8 ±1.7 years. A CV health metric at baseline was calculated including 3 health factors (glucose, LDL cholesterol, and blood pressure), 4 health behaviors (BMI, physical activity, adherence to a Mediterranean diet, and cigarette smoking), and one marker assessing in-part early life environment (body height), categorizing each of these 8 factors into ideal (2 points), intermediate (1 point), and poor levels (0 points).
Results: Among 310 patients (mean age 62 yrs, 96.5% men) higher CV health scores were positively associated with educational level (p<0.001) and inversely with age (p=0.003), while no significant associations were identified with ultrasound indices of cerebrovascular disease (impaired CVR, increased common carotid IMT and carotid plaques). In linear regression models adjusted for age, educational level, sex and BIP study arm, increment in the overall CV health score (per 1 point) was associated with higher scores in executive function (p=0.002), memory (p=0.06), visuospatial function (p=0.005), attention (p=0.024) as well as in a global cognitive function score [B coefficient ± SE, 1.19±0.35 (p=0.001)] assessed a decade later. Increment (per 1-point) in the health behavior component was associated with 1.28±0.49 (p=0.009) higher cognitive score, in the early life environment component with 2.55±0.75 (p=0.001) higher cognitive score, while the health factors component was not associated with subsequent cognitive scores [0.24±0.52 (p=0.64)]. In sensitivity analyses excluding patients with stroke similar findings were observed.
Conclusion: Among patients with pre-existing CHD, better CV health is associated with subsequent higher cognitive functions. Our findings suggest that health behavior and early life environment are important determinants of late-life cognitive function.
Author Disclosures: D. Tanne: None. G. Weinstein: None. N. Molshatzki: None. U. Goldbourt: None.
- © 2014 by American Heart Association, Inc.