Abstract T P242: High Mortality Rates Among Acute Intracerebral Hemorrhage Patients with PT-INR Vales of More than 2.0 Taking Warfarin
Background and objectives: The relationship between the prothrombin time (PT)-international normalized ratio (INR) at intracerebral hemorrhage onset and patient outcome is unknown. Therefore, we investigated this relationship in the present study.
Methods: Clinical backgrounds, physical and imaging findings, and outcomes were compared among 76 consecutive patients who were administered warfarin within 24 hours of acute intracerebral hemorrhage onset and had PT-INR values of <2.0, 2.0-2.6, and ≥2.6 at admission.
Results: The PT-INR <2.0, and 2.0-2.6 and ≥2.6 groups comprised 23, 23, and 30 patients, respectively (female, 35%, 26%, and 53%, respectively; median age, 75, 73, and 75 years, respectively). The Glasgow Coma Scale (GCS) medians of the PT-INR <2.0, 2.0-2.6, and ≥2.6 groups were 14 (25th-75th percentile: 13-15), 12 (4-14), and 10 (4-14) (p = 0.01), respectively, and hematoma volumes were 6.8 (2.0-26.8), 28.8 (7.0-111.9), and 25.3 (6.0-100.0) mL, respectively (p = 0.03). No other significant differences were observed in regards to the patients’ clinical backgrounds. The in-hospital mortality rates were 17% (n = 4), 57% (n = 13), and 53% (n =16), respectively (p = 0.01) (Fig.).
Conclusion: The in-hospital mortality rate was significantly higher for acute intracerebral hemorrhage patients taking warfarin with PT-INR ≥2.0 than for the other patients. To avoid significantly higher mortality rates, alternatives to warfarin should be considered.
Author Disclosures: S. Yamashita: None. N. Matsumoto: None. N. Saji: None. J. Uemura: None. K. Shibazaki: None. K. Kimura: None.
- © 2014 by American Heart Association, Inc.