Abstract T P285: In-hospital Complications Affected Stroke Recurrence in Patients With Ischemic Stroke
Objective: In-hospital medical complications are common and costly. Outcomes of stroke patients are affected by medical complications. However, there are limited data investigating the effect of medical complications on stroke recurrence worldwide. We prospectively and systematically investigated the effect of in-hospital medical complications on recurrent stroke of patients with acute ischemic stroke at 3, 6 and 12 months in the China National Stroke Registry (CNSR).
Methods: Prospective cohort study collected data of adult patients with acute ischemic stroke in 132 clinical centers distributed in 32 provinces and 4 municipalities (including Hong Kong region) of China, from September 2007 to August 2008. Data on in-hospital medical complications, recurrent stroke, adherence to stroke secondary prevention and other relative information were obtained from paper-based registry forms. Medical complications were associated with stroke outcomes using multivariable logistic regression.
Results: Of the 10306 study patients, recurrent stroke occurred in 1637 (15.9%) within 12 months after stroke onset. In-hospital medical complications were independent risk factors for stroke recurrence in patients with acute ischemic stroke at 3 months (adjusted OR=2.19; 95% CI 1.85 to 2.60), 6 months (adjusted OR=2.04; 95% CI 1.74 to 2.38), and 12 months (adjusted OR=1.88; 95% CI 1.62 to 2.19) after onset. In-hospital medical complications decreased the adherence to stroke secondary prevention, may indirectly resulting in increased recurrent stroke events.
Conclusions: The results demonstrated that the short-term and long-term stroke recurrence of acute ischemic patients is significantly affected by in-hospital medical complications, possibly through decreasing the persistence of secondary prevention following acute ischemic stroke.
Author Disclosures: P. Wang: None. X. Zhao: None. Y. Wang: None. L. Liu: None. A. Wang: None. R. Ji: None. Y. Wang: None. W. Du: None. K. Dong: None.
- © 2014 by American Heart Association, Inc.