Abstract T P45: Task Fmri Based Functional Connectivity in Acute Stroke Patients With and Without Motor Impairments
Introduction: Several studies employing functional/effective connectivity methods have reported performance-related changes in the motor network after stroke. We investigated changes in the motor network in a group of acute stroke patients (less than 7 days from stroke onset) with and without motor impairments compared to age-matched healthy controls.
Methods: Seed regions for task-based functional connectivity were based on peak coordinates of significant clusters of activation associated with right-hand finger tapping task in the scanner, derived from 13 left hemisphere stroke patients (mean age 63 yrs, 11 right handed) and 13 age-matched healthy controls. These regions were then used to examine seed-based functional connectivity in 23 patients (12 with motor impairment [7 LH strokes, avg. age of 59, 10 rt handed], and 11 without [7 LH strokes, avg. age of 63, 9 rt handed]. Motor impairment was based on self-reported scores on the hand strength and hand function domain of the Stroke Impact Scale(Duncan et al., 2003). The Network Based Statistics Toolbox (Zalesky, Fornito, & Bullmore, 2010), which uses a non-parametric approach based on permutation tests, was used to test differences in functional connectivity.
Results: Compared to patients without motor impairments, patients with impairments showed reduced connectivity (p < .05, corrected) in a network comprising of connections between the right inferior parietal and right cerebellum, right precentral central (PCG) and left thalamus, left post central gyrus and right cerebellum, left SMA and right cerebellum. Compared to controls, patients with impairments showed reduced connectivity (p < .05, corr) in a network comprising of connections between the right PCG and left thalamus, right PCG and bilateral cerebellum. There were no differences in functional connectivity patterns in stroke patients without motor impairments compared to healthy controls.
Conclusions: Compared to patients without motor impairments, patients with motor impairments showed reduced intra- and inter-hemispheric functional connectivity. When compared to healthy controls, patients with motor impairments showed reduced intra-hemispheric connectivity in the ipsilateral hemisphere.
Author Disclosures: V.A. Nair: None. C. La: None. B.M. Young: None. M. Andreoli: None. P. Reiter: None. M.B. Jensen: None. M. Chacon: None. J. Sattin: None. V. Prabhakaran: None.
This research has received full or partial funding support from the American Heart Association, Midwest Affiliate – Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, South Dakota, Wisconsin.
- © 2014 by American Heart Association, Inc.