Abstract W MP11: Post Stroke Emotional Dysfunction and Fatigue Are Related to Tryptophan Hydroxylase 2 Polymorphsis
Background and Purpose: Emotional dysfunction is a common complication after stroke. Despite reports on serotonergic involvement in the etiology post stroke emotional dysfunction (PSED) and post stroke fatigue (PSF), the role of the TPH1 and TPH2 gene responsible for 5-HT synthesis in PSED and PSF requires analysis. The aim of this study was to investigate the association between different genetic variants of the Tryptophan Hydroxylase (TPH) 1 and TPH2 gene and PSED and PSF at 3 months post- stroke.
Method: TPH1 A218C and TPH2 SNPs, rs4641528 and rs10879355 genotyping were performed from genomic DNA which was collected and stored previously from 373 stroke patients. The potential association between TPH1 and TPH2 polymorphisms and post-stroke depression (PSD), post-stroke emotional incontinence (PSEI), and PSF was investigated.
Results: PSD, PSEI, and PSF were present in 17.2%, 10.7%, and 44.0% at 3 months post-stroke. Among the patients, 10 (2.7%) had all three PSEDs (PSD, PSEI, and PSF), 37 (9.9%) had two of the three, and 119 (31.9%) had only one among PSD, PSEI, and PSF at 3 months post-stroke.There were no significant differences in the TPH1 A218C genotype or allele frequencies between the patients with PSD, PSEI, or PSF and those without them at 3 months post-stroke. TPH2 SNP rs10879355 was associated with post-stroke fatigue (p<0.01) at 3 months post-stroke, whereas TPH2 SNP rs4641528 was associated PSD (p=0.018) and PSEI (p=0.049).
Conclusions: Our results suggested that TPH2 SNPs may have an important effect on PSED and PSF at 3 months post-stroke, but the TPH1 A218C polymorphism plays no significant role in the pathogenesis and clinical symptomatology of PSED and PSF.
Author Disclosures: S. Choi-Kwon: None. M. Ko: None. S. Choi: None. J. Kim: None.
- © 2014 by American Heart Association, Inc.