Abstract W P140: Neuroanatomical Correlates of Atrial Fibrillation: A Longitudinal MRI study
Background: We hypothesized that atrial fibrillation maybe associated with structural changes in particular regions of the brain.
Objectives: To determine baseline volume and rate of volume change of whole brain, hippocampus, and entorhinal cortex.
Methods: We analyzed clinical and neuroimaging data collected as part of Alzheimer’s Disease Neuroimaging Initiative from 200 normal controls and 400 individuals with mild cognitive impairment (MCI) recruited at approximately 50 sites in the United States and Canada. Patients with atrial fibrillation were identified based on baseline clinical/cognitive assessments and age and gender matched controls without atrial fibrillations were selected (1:1 ratio). All participants underwent 1.5 T structural MRI at specified intervals (6 or 12 month) for 2-3 years.
Results: A total of 40 persons with atrial fibrillation were included [Age mean (±SD) 78±6, 23 (57.5) were men]. There were no patients with stroke and 10 controls who had a previous history of stroke. There was no difference in whole brain and ventricular volumes at baseline MRI between cases and controls. There was significantly lower entorhinal cortex volume on right (p=0.001) and left (p=0.002) sides in patients with atrial fibrillation. There was significantly lower volume for middle temporal lobes on right (p=0.001) and left (p=0.001) sides. The rate of progression of atrophy in entorhinal cortex and middle temporal lobes was not different between patients with atrial fibrillation and controls.
Conclusions: The association of atrial fibrillation with volume loss in entorhinal cortex and middle temporal lobes may provide new insights into pathophysiology of atrial fibrillation.
Author Disclosures: A. Saed: None. N. Tasneem: None. M.M. Adil: None. M.H. Qureshi: None. A.I. Qureshi: None.
- © 2014 by American Heart Association, Inc.