Abstract W P143: Race-specific Effects of Inflammatory and Vascular Remodeling Biomarkers in Ischemic Stroke
Background: Blacks have a higher risk of stroke than whites; inflammatory and vascular remodeling (VR) biomarkers may mediate this risk. We aimed to determine associations between inflammatory and VR biomarkers and ischemic stroke in a bi-racial sample of the Atherosclerosis Risk In Communities (ARIC) cohort.
Methods: In a case-control pilot study, 133 participants from Forsyth and Jackson Field Centers were identified: 32 blacks and 33 whites with first ischemic stroke after visit 2, and 33 black and 35 white stroke-free controls. We assayed IL-8, IL-10, IL-1 receptor antagonist (IL-1ra), IL-1β, matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) with Quantikine ELISA. We calculated IL-1β/IL-1ra ratio, representing the IL-1 pathway. Biomarkers were covariates in race-specific logistic regression models; if significant, biomarker-by-race interactions were explored.
Results: Cases were older (mean age 60y vs 56y; p<0.0001); more had hypertension (52% vs 35%; p=0.043), and diabetes (35% vs 13%; p=0.0034). There were no differences in biomarkers between blacks and whites (cases and controls). In blacks, there was a trend toward a reduced risk of stroke with increasing levels of IL-1ra after adjustment (p=0.074). In whites, stroke was associated with higher levels of TIMP-1 (p=0.011; interaction p=0.079) and with higher levels of IL-8 (p=0.011; interaction p=0.11) in the unadjusted, but not adjusted model (Table).
Conclusion: We identified race-specific associations between biomarkers and incident stroke. VR biomarkers (TIMP-1) may be associated with stroke in whites, and there was a trend towards lower levels of IL-1ra (counter-inflammatory) and risk of stroke in blacks. Larger studies are warranted to confirm these findings and determine if these markers will explain differences in stroke risk in blacks vs whites.
Author Disclosures: C. Bushnell: None. B.M. Snively: None. B.B. Worrall: None. C. Colton: None. R. Hoogeveen: None. T. Mosley: None. R. Gottesman: None. A. Folsom: None. L. Wagenknecht: None.
- © 2014 by American Heart Association, Inc.