Abstract W P145: Shift in Sex Ratio Over Time in Cerebral Venous Thrombosis
Background: In contemporary studies on cerebral venous thrombosis (CVT) there is a predominance of female patients. The change in sex ratio over time, however, has not been systematically studied
Methods: We performed a systematic review of the literature up to April 2013. Studies with ≥ 40 CVT patients that reported outcome were eligible. Pediatric studies, studies which selectively included women and those in which no sex ratio was reported were excluded. We ranked studies according to the year halfway the period of patient inclusion. If no time span was reported, we assumed a period of inclusion of 10 years prior to the year of publication.
Results: Fifty-three studies, with a total of 20.881 patients were included. The mean age was 36 years (SD 4.7) and 71% of patients were women. In studies that reported gender specific risk factors, 25% had a pregnancy related CVT and 37% used oral contraceptives at the time of diagnosis. There was a significant correlation between the period of the study and the percentage of women (Pearson correlation coefficient 0.37, p=0.006, figure). Similarly, there was a significant increase of oral contraceptive use among female patients, from a mean of 14% in studies before 1970 to a mean of 39% in those after 2001 (correlation coefficient 0.34, p=0.05). In contrast, the percentage of pregnancy related CVT cases did not increase over time (correlation coefficient 0.01, p=0.96).
Conclusions: The sex ratio among CVT patients has significantly shifted over time, with a gradual increasing percentage of women. Our results suggest that this change is related to the increased proportion of women using oral contraceptives.
Author Disclosures: J.M. Coutinho: None. S.M. Zuurbier: None. J. Stam: None.
- © 2014 by American Heart Association, Inc.