Abstract W P152: Obesity Increases Risk of Ischemic Stroke in Young Adults
Background and Purpose: Increased body mass index (BMI) has been associated with ischemic stroke in older populations, but its association with stroke in younger populations, in whom the life-long burden of obesity-associated risk factors is presumably lower, is not known. In light of the current obesity epidemic and evidence for an increasing incidence of stroke in young adults, this topic deserves further investigation.
Methods: We investigated the association between BMI and early-onset ischemic stroke using data from a case-control study in the greater Baltimore-Washington area. Cases ages 15-49 (n=1201) and age-gender-race balanced controls (n=1154) were recruited between 1992 and 2008. Presence of hypertension and diabetes was obtained by interview. Study participants were placed into CDC-defined weight categories of underweight (BMI < 18.5 kg/m2), normal weight (18.5 to 24.9), overweight (25.0 to 29.9), and obese (BMI ≥ 30 kg/m2). Logistic regression modeling was used to evaluate the association between BMI and ischemic stroke.
Results: Unadjusted analysis indicated a significant association between BMI and ischemic stroke; the overweight group had an OR of 1.2 (95% CI 1.0- 1.5) and the obese group had an OR of 1.8 (95% CI 1.5- 2.2) when compared to the normal weight reference group. But these heightened risks were highly attenuated after further adjustment for hypertension and diabetes mellitus. There was no significant difference in stroke risk between the overweight and normal weight groups. Obese males (OR of 1.3, 95% CI 0.9- 1.8), but not obese females, had an increased stroke risk compared to their normal weight counterparts.
Conclusion: We observed a moderate association between BMI and early-onset ischemic stroke that increased in a dose-response fashion. The attenuation of stroke risk in high BMI groups following adjustment for hypertension and diabetes suggest that the effects of obesity may be mediated in part through these and other obesity-related conditions.
Author Disclosures: A.B. Mitchell: None. J.W. Cole: None. P.F. McArdle: None. Y. Cheng: None. B.D. Mitchell: None. S.J. Kittner: None.
- © 2014 by American Heart Association, Inc.