Abstract W P153: Parental History of Stroke and Incident Atrial Fibrillation According to Blood Pressure Category in a General Urban Population: The Suita Study
Background and purpose: No prospective study has examined the relation between a parental history of stroke and the incidence of atrial fibrillation (AF) in a general population. We assessed the hypothesis that a parental history of stroke is associated with an increased risk of incident AF according to blood pressure (BP) category in a general population.
Methods: A total of 6,918 participants (30 to 84 years old) initially free of AF were prospectively followed up for incident AF in the Suita Study. Standard 12-lead electrocardiograms were obtained from all subjects in the supine position. Each record was coded independently by 2 well-trained physicians using the Minnesota Code. Participants were diagnosed with AF if AF or atrial flutter was present on electrocardiograms obtained during a biannual routine health examination or if AF was indicated as a present illness by either annual questionnaires responses or participants' medical records. Well-trained nurses obtained information on parental history of stroke and on the participants' lifestyle. BPs were taken as the average of the second and third measurements. The category of systolic BP (SBP) was defined by the following criteria: normal SBP (<120 mm Hg), systolic prehypertension (120-139 mm Hg), and systolic hypertension (≥140 mm Hg and/or antihypertensive medications). Cox proportional hazard ratios (HRs) and 95% confidence intervals (CIs) were analyzed after adjusting for age, sex, body mass index, BP categories, diabetes, hyperlipidemia, smoking, and drinking status at baseline.
Results: In 87,341 person-years of follow-up, 245 incident AF events occurred. A parental history of stroke was significance to the incidence of AF in men (adjusted HR, 1.47; 95% CIs, 1.03-2.10). Compared with normal SBP subjects without a parental history of stroke, the adjusted HRs (95% CIs) of incident AF in systolic hypertensive subjects were 2.18 (1.36-3.51) and 1.50 (1.01-2.23) for those with and without a parental history of stroke (P for interaction between parental history of stroke and SBP = 0.06).
Conclusions: A parental history of stroke is a predictor of incident AF among systolic hypertensive subjects. For persons with a parental history of stroke, BP control would be important for AF prevention.
Author Disclosures: Y. Kokubo: None. M. Watanabe: None. T. Kobayashi: None. S. Kamakura: None. T. Aiba: None. K. Kusano: None. K. Kawanishi: None. Y. Miyamoto: None.
- © 2014 by American Heart Association, Inc.