Abstract W P165: Predictors of Cerebral Microbleeds in Patients With Ischemic Stroke
Background and purpose: similarities in renal and vascular beds could explain the relationship between impaired glomerular filtration rate (iGFR) and leukoaraiosis, white matter hiperintensities (WMH), and lacunar infarcts. We evaluated the association between microbleeds (MB) and impaired kidney function in patients with acute ischemic stroke.
Methods: acute ischemic stroke patients were prospectively included. Pre-stroke vascular risk factors were obtained and the presence of MB and WMH were evaluated on admission MRI and analyzed as dichotomous variables.
Results: MB were present in 128 (19%) of the 663 patients evaluated.. Table shows risk factors and comorbidities associated with MB in the univariate analysis. Only leukoaraiosis (OR 3.3; CI 95% 1.5-3.3; p 0.0001), age older than 80 years (OR 1.90; CI 95% 1.10-2.8; p 0.01), WMH (OR 9.4; CI 95% 5.6-15.6; p 0.0001) and iGFR (OR 2.2; CI 95% 1.3-3.3; p 0.01) were associated with the presence of MB in the multivariate analysis.
Conclusion: Besides age and WMH, well-known risk factors for MB, impaired kidney function doubles the risk these lesions in a cohort of ischemic stroke patients, reassuring the hypothesis of a common pathophysiological pathway for renal and cerebral microvascular damage.
Author Disclosures: M.C. Zurru: None. C. Alonzo: None. L. Brescacin: None. S. Pigretti: None. A. Luzzi: None. L. Camera: None. G. Waisman: None. E. Cristiano: None.
- © 2014 by American Heart Association, Inc.