Abstract W P325: Is Obesity a Marker of Good or Bad Functional Outcome After Ischemic Stroke?
Background: Obesity is at epidemic proportions in our society. There have been conflicting reports on the association between obesity and stroke outcome. We hypothesized that obesity at the time of stroke leads to better relative short-term functional outcome, but poorer longer-term functional outcome, after stroke.
Methods: A cohort of 964 patients, identified by hot-pursuit in the ED in 2005 and 2010, was followed out to three months post stroke. Functional outcome, as measured by the modified Rankin scale (mRS), was collected at discharge from hospitalization and at 3 months post stroke. Height and weight were collected at time of stroke and body mass index (BMI) was calculated. Normal weight was defined as BMI ≤ 25 kg/m2, overweight as BMI 25 to 29 kg/m2, and obese as BMI ≥ 30 kg/m2. Covariates and confounders considered were age, gender, race, pre-stroke mRS, baseline NIH Stroke Scale Score (NIHSSS), heart disease, diabetes, hypertension, and smoking. Good functional outcome was defined as a mRS score of 0-1 or back to baseline. Multiple logistic regression was used for analysis to assess the association of BMI status and good functional outcome.
Results: The cohort was 50% female and 21% black and mean (SD) age was 67 (14) years. Prior to stroke mRS was 0 or 1 in 60%. Of the 964 patients; 882 (91%) had valid height and weight to calculate BMI and were alive at discharge; 224 (25%) were normal weight, 324 (37%) overweight and 314 (36%) obese. There was no statistically significant association between functional outcome, either at hospital discharge after stroke or at 3 months post stroke, and obesity status; even after adjusting for the covariates listed above (see table).
Conclusions: Obesity status at time of stroke is not statistically significantly associated with hospital discharge or three-month functional outcome after stroke. Longer term outcome is to be examined.
Author Disclosures: S. Yeramaneni: None. B.M. Kissela: Research Grant; Significant; NS30678. D.O. Kleindorfer: Research Grant; Significant; NS30678. K. Alwell: Research Grant; Significant; NS30678. C.J. Moomaw: Research Grant; Significant; NS30678. M. McCarthy: None. H. Sucharew: Research Grant; Significant; NS30678. C. Lindsell: None. D. Woo: Research Grant; Modest; NS30678. P. Khatri: None. M. Flaherty: Research Grant; Modest; NS30678. S. Ferioli: Research Grant; Modest; NS30678. S. Martini: Research Grant; Modest; NS30678. F. de Lod Rios La Rosa: None. J. Mackey: None. J.C. Khoury: Research Grant; Significant; NS30678.
- © 2014 by American Heart Association, Inc.