Abstract W P338: Association of Triglyceride-HDL Cholesterol and LDL Cholesterol HDL Cholesterol Ratios With Symptomatic Intracranial Atherosclerosis
Background: Emerging data suggest that a triglyceride (TG): HDL-C ratio and LDL: HDL-C ratio may be a better predictor of vascular risk than the traditional lipid measures such as total cholesterol and LDL-C.
Methods: A cohort of 40 Patients was selected with symptomatic intracranial atherosclerotic disease (ICAD) who underwent intracranial stent placement and lipid profiles within 90 days of the treatment,. Age and gender matched asymptomatic controls were selected from the Multi-Ethnic Study of Atherosclerosis (MESA) involving more than 6,000 men and women from six communities in the United States.
Results: Case control continuous variable analysis in a logistic regression model demonstrated higher TG/HDL-C ratio was directly associated with ICAD (OR 1.36, 95% CI 1.13-1.65 p= 0.001) while higher LDL/HDL ratio was not associated with ICAD (OR 1.14, 95% CI 0.77-1.69 p= 0.495). After adjusting for diabetes mellitus, hypertension, smoking, cigarette smoking and alcohol use, higher TG/HDL ratio was directly associated with ICAD (OR 1.26, 95% CI 1.0-1.58 p= 0.048) but the LD/HDL ratio was not associated with ICAD (OR 0.85, 95% CI 0.48-1.64 p= 0.696).
Conclusion: TG: HDL-C ratio was associated with symptomatic ICAD and may represent a therapeutic target for optimizing intensive medical treatment.
Author Disclosures: V.B. Jani: None. S.S. Chaudhry: None. V. Jadhav: None. S. Hussain: None. A. Safdar: None. A.I. Qureshi: None.
- © 2014 by American Heart Association, Inc.