Abstract W P354: Effect of Free Fatty Acid on Recurrent Stroke in Stroke Patients With Atrial Fibrillation
Background: Although free fatty acid (FFA) has been considered to have a link with atherosclerosis, recently, an association between FFA and atrial fibrillation was reported. In this study, we tried to determine whether FFA could be associated with recurrent stroke in stroke patients with atrial fibrillation.
Methods: Retrospective analyses of 279 stroke patients who had atrial fibrillation from multicenter hospital-based stroke registry. We examined the effect of FFA on recurrent stroke using survival analysis.
Results: Twenty-two patients had recurrent stroke (7.9%) during the study periods (mean follow-up duration 16.7 months). The baseline plasma FFA concentration was significantly higher in patients with recurrent stroke (1.54 ± 0.81 mEq/L 1.54 ± 0.81 mEq/L) than those without recurrent stroke (1.09 ± 0.76 mEq/L). In Cox’s survival analysis, plasma FFA concentration (mEq/L) was significantly associated with recurrent stroke in univariate model (HR 1.521, 95% CI 1.094 - 2.114) and model after adjustment for CHADS2 score (HR 1.509, 95% CI 1.056 - 2.156).
Conclusion: The present study suggested that elevated FFA concentration could be indicator for recurrent stroke in stroke patients with atrial fibrillation.
Author Disclosures: W. Seo: None. J. Choi: None. J. Jung: None. K. Cho: None. K. Oh: None.
- © 2014 by American Heart Association, Inc.