Abstract W P79: Computational Fluid Dynamics Analysis in Roles of Hemodynamic Factors on the Development of Cerebral Aneurysms
Cerebral aneurysms are known to be more induced in the asymmetric-shaped circle of Willis, suggesting that hemodynamic stress is involved in aneurysm development. We have made a series of reports on an animal model of experimentally induced cerebral aneurysms, which are induced in the circle of Willis where blood flow is increased in compensation for ligation of unilateral common carotid artery and renal hypertension. Our morphological and molecular studies suggest that enhanced wall shear stress (WSS) at the local area in the circle of Willis initiates aneurysm development (Fukuda S, Circulation 101:2532-2538). We examined here roles of hemodynamic factors on the development of cerebral aneurysms with computational fluid dynamics (CFD) techniques using 3-dimentional CT angiographic images of human cerebral aneurysms.
In order to clarify the effect of hemodynamic factors on aneurysm growth, we virtually reconstructed arterial geometry of human middle cerebral and internal carotid artery aneurysms just before the development of aneurysms by artificial removal of the aneurysm as we reported previously (Shimogonya Y, J Biomech 42:550-554), and compared values of hemodynamic factors between aneurysm-developed side and non-developed normal side. Time-averaged WSS gradient was significantly higher in the aneurysm-developed side than normal side. The data suggest that an increase in wall shear stress be associated with an early stage of the aneurysm formation, which is consistent with our previous data using an animal model.
Author Disclosures: S. Fukuda: None. Y. Shimogonya: None. T. Tsukahara: None. Y. Imoto: None. M. Fukuda: None.
- © 2014 by American Heart Association, Inc.