Letter by Heo et al Regarding Article, “Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke”
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To the Editor:
We read with great interest the recent article by Llull et al1 based on the Efficacy Study of Combined Treatment with Uric Acid and rtPA in Acute Ischemic Stroke (URICO-ICTUS) trial.2 The authors report that uric acid (UA) treatment was effective in female patients who received recombinant tissue-type plasminogen activator by preventing infarct growth, which led to excellent outcome. The results support the hypotheses that the poorer outcome in female patients rather than male patients treated with recombinant tissue-type plasminogen activator can be explained by the low levels of UA and that the outcome may be improved by treating with UA. The UA level has been known to be associated with the risk of …