Abstract 57: The Effect Of Routine Oxygen Supplementation on Long Term Functional Outcomes and Quality of Life After Stroke: 6 and 12 Month Outcomes The Stroke Oxygen Study
Introduction: Routine oxygen supplementation (ROS) is commonly prescribed to prevent stroke-related hypoxia and secondary brain damage. However, early results of The Stroke Oxygen Study (SO2S) show that routine oxygen supplementation does not affect mortality and disability at 3 months.
Objectives: to establish whether routine oxygen supplementation early after acute stroke improves long-term functional outcome and quality of life after stroke.
Methods: SO2S is a large multicentre randomized controlled trial. Patients with acute stroke were eligible for inclusion within 24h of hospital admission if they had no definite indications for or contraindications to oxygen treatment. Participants were randomised 1:1:1 to continuous oxygen, oxygen at night (between 21:00-06:00) only, or to control (room air) for 72 h. Oxygen was given at a rate of 3L/min if the baseline oxygen saturation was ≤93% and at 2L/min if it was >93%. Follow-up was at 3, 6 and 12 months by postal questionnaire with telephone follow-up for non-responders.
Results: 8003 participants were recruited from 136 hospitals in the UK from April 2008 to June 2013. The median age was 74 (range 19-100) y, 4398 (54.9%) were male, and the baseline NIHSS score was 5 (range 0-34). We will present long-term outcomes including mortality, disability (mRS), the ability to perform activities of daily living (BI, NEADL) and quality of life (EQ5D). Comparisons will be between ROS and control, and between nocturnal versus continuous ROS. A longitudinal repeated measures analysis across all three time points (3, 6 and 12 months) will also be presented.
Conclusion: The results of this large study will give a definitive answer to the question whether routine oxygen supplementation affects long-term outcome. They will also show whether there is a difference in the level of effectiveness when oxygen is given continuously rather than at night only, when patients are most likely to become hypoxic.
Author Disclosures: T. Nevatte: None. J. Sim: None. R. Gray: None. N. Ives: None. J. Bishop: None. S. Pountain: None. P. Crome: None. C. Roffe: None.
- © 2015 by American Heart Association, Inc.