Abstract T MP45: Incidence, Predictors And Mortality Related To Post-stroke Antidepressant Treatment
Objective: To examine incidence, predictors and mortality related to antidepressant treatment after ischemic stroke in a clinical setting.
Methods: Patients were identified from the Danish Stroke Registry which holds information on antidepressant treatment due to post stroke depression (PSD) and pathological crying (PC) from 2003-2010. Treatment initiation and mortality were analyzed using Kaplan-Meier curves and Cox regression. Potential predictors of antidepressant treatment were identified using multiple logistic regression.
Results: Among 5070 first ever stroke patients without prior antidepressant treatment, 32.5% were treated with antidepressants within six months after stroke, primarily with selective serotonin reuptake inhibitors. Approximately half of the treated patients started treatment during stroke admission (mean time after stroke: 7 days for PC and 10 days for PSD). The vast majority of treated patients started treatment within 90 days (86%). Among patients treated during admission 93.1% redeemed at least one prescription after discharge. The predictor most strongly associated with treatment was stroke severity. The adjusted hazard ratio of death was 0.39 (95% CI: 0.31-0.48) for treated patients as compared to non-treated patients.
Conclusion: Antidepressant treatment after stroke was common and often initiated early. Although increasing stroke severity was a strong predictor of antidepressant treatment, treatment was associated with a lower mortality.
Author Disclosures: J.K. Mortensen: None. H. Larsson: None. S.P. Johnsen: None. G. Andersen: None.
- © 2015 by American Heart Association, Inc.