Abstract T MP49: Should Transesophageal Echocardiography (TEE) be the Initial Diagnostic Modality of Choice in Young Ischemic Stroke (IS) Patients?
Background&Purpose: Current data is limited regarding the comparative utility of Transthoracic echocardiography (TTE) vs. TEE in diagnosing potential sources of cardioembolism (PSOC) in patients with cryptogenic stroke, particularly in young stroke patients. We sought to evaluate the comparative diagnostic yield of these two echocardiographic modalities in young IS patients.
Methods: We conducted a retrospective chart review of consecutive young (18-45 yrs) IS patients admitted to a tertiary care stroke center over a study period of 42 months. All patients underwent both TTE and TEE during their standard diagnostic work-up. Stroke classification at discharge was performed according to TOAST criteria by treating physicians.
Results: The study population consisted of 83 IS patients (mean age 38±5years, 40% men, 86% blacks, median admission NIHSS-score 3 points, IQR 1-8) who underwent both echocardiographic examinations. Cardioembolic stroke (CS) was the discharge diagnosis in 22 cases (27%). EF calculated by TEE strongly correlated to EF calculated by TTE (r=0.846; p<0.001). Left atrial enlargement was detected more frequently by TEE than TTE (27% vs. 11%; p<0.001). The overall yield of TEE for detecting PSOC was higher than TTE (23% vs 4%; p=0.011). TTE diagnosis of a PSOC was not associated with CS discharge diagnosis in univariate analyses (OR: 6.0, 95%CI: 0.5-69.8; p=0.152). TEE diagnosis of PSOC was associated with CS in univariate analyses (OR: 13.2, 95%CI: 4.0-43.8; p<0.0001). After adjustment for demographics, vascular risk factors, admission NIHSS-score, admission SBP and DBP levels, admission blood glucose and abnormal TTE, TEE diagnosis of a PSOC was independently associated with a higher likelihood of CS diagnosis at hospital discharge (OR: 24.3, 95%CI: 5.9-100.0; p<0.0001).
Conclusions: Our study showed that the yield of TEE for detecting PSOC was higher than that of TTE, while abnormal TEE findings were independently associated with a higher likelihood of CS diagnosis. TEE should be considered as the initial echocardiographic modality for evaluating young IS patients, since it may expedite workup and early detection of stroke etiopathogenic mechanism.
Author Disclosures: R. Bhole: None. N. Goyal: None. R.W. Gilbert: None. G. Tsivgoulis: None. M.D. Malkoff: None. A.V. Alexandrov: None.
- © 2015 by American Heart Association, Inc.