Abstract T P213: An Interactive Video Improves the Understanding of a Hypothetical Adaptive Acute Stroke Trial
BACKGROUND AND PURPOSE: The communication of adaptive clinical trials can be more difficult due to the increased complexity of the design itself, especially in an emergent, time-sensitive setting such as with acute stroke patients. We hypothesized that introducing brief, comprehension questions into a video explaining a hypothetical acute stroke trial would improve the understanding of the trial allocation procedure and increase patient participation.
METHODS: We conducted a cross-sectional survey of adult patients presenting to the emergency department. After obtaining verbal consent, patients were randomized to one of four groups: They watched a video with either an RAR or a standard hypothetical acute stroke trial, with or without the addition of interactive comprehension questions. These questions addressed research procedures relevant to the consent process and operation of the trial. Subjects were asked whether they would consent to the trial and if they could identify the method of randomization and allocation used.
RESULTS: A total of 720 patients were enrolled. A significantly higher proportion of individuals in the RAR interactive video group (85.9%) correctly identified the trial allocation method assigned versus the RAR uninterrupted video group (60.4%), absolute increase: 25.5% (95% confidence interval, 17-33%). Additionally, there was significantly higher trial participation in the RAR interactive video group (table).
CONCLUSIONS: Integrating structured comprehension questions into the consent process of a hypothetical acute stroke trial increased understanding of the RAR trial design and further attracted more research participation. Improving the communication of the trial procedures within a simulated situation that mimics the rapid discussion regarding an emergency research trial is beneficial and should be incorporated into future acute stroke trials
Author Disclosures: B. McEvoy: None. J. Tehranisa: None. W.J. Meurer: None.
- © 2015 by American Heart Association, Inc.