Abstract T P224: The Effect of Hyperbaric Oxygen Therapy Following an Ischemic Stroke
Hyperbaric oxygen therapy (HBOT) has been approved and is widely used for several conditions such as decompression sickness, gas embolism, wound repair, carbon monoxide poisoning, and burns. There are other reported applications of HBOT including cerebral palsy, autism, migraines, traumatic brain injury, and stroke. While experimental and observational studies suggest a benefit of HBOT for these conditions, controlled clinical trials have not been able to clearly define the benefits. Therefore, future research in these areas is essential to identify and fully understand the therapeutic potential of HBOT. In this study we propose to investigate the effects of HBOT on physical and cognitive impairments resulting from an ischemic stroke. A single case study design was utilized for 8 subjects. Subjects (male or female, 18 - 90yrs of age) were included in this study if they had suffered an ischemic stroke approximately 12-month ago and exhibited some functional impairments. A constant baseline was established which was defined as no functional improvement over a 3 month period. During the study each subject received two 4-week periods of HBOT for a total of 40 treatments of hyperbaric oxygen over a 12-week period. Each participant completed a battery of cognitive, physical, speech, and quality of life measures six times over 9 months, and had blood drawn for biochemical analysis 6 times throughout the study. We found improvements in cognition and executive function as well as physical abilities specifically, gait. Participants reported improved quality of life and decreased following HBOT treatment. We also saw changes in serum levels of biomarkers for inflammation and neural recovery, which appear to correlate with functional changes. In most domains improvement occurred during HBOT treatment but after 3 months following the last treatment, the observed changes were decreased similar to baseline levels. Findings from this study support the idea of HBOT as a potential intervention following stroke however, the timing of this treatment needs to be further examined. Further, the mechanism through which HBOT is eliciting functional changes has yet to be fully determined.
Author Disclosures: E.R. Rosario: None. S. Kaplan: None.
- © 2015 by American Heart Association, Inc.